Clinical phenotypes of cow’s milk food allergy in children depending on the molecular profile of sensitization

Introduction.
 Sensitization to cow’s milk (CM) is one of the most common causes food allergy (FA) in young children; its clinical manifestations children are varied, since many organs and systems can be involved pathological process.
 The purpose: study profile IgE sensitization molecular components CM children, depending on phenotype disease.
 
 Materials Methods.
 Clinical laboratory examination 148 from birth 12 months with IgE-mediated FA was carried out. sIgE milk, nBos d 8, 4, 5, 6 out by Immuno CAP method. Statistical processing performed using Statistica for Windows v. 10.0, StatSoft Inc. (USA).
 Results:
 conducted analysis allowed us identify skin (33.3%; 49/148), gastrointestinal (23.5%; 35/148) mixed (43.2%; 64/148) CMA children. In structure phenotypes, frequency prevailed over (χ2 = 20.51, p < 0.00001) 27.84, 0.00001). 4 has greatest influence formation 18.67, 0.0001). manifestations, combined 8 + 14.96, 0.0003), 5 28.44, more common.
 Conclusion.
 results showed importance disease used personalize diagnosis therapeutic strategy.